What are the criteria for confirming FRE?

What are the criteria for confirming FRE?

• A. Clinical resolution only
• B. Relapse on dietary challenge only
• C. Clinical resolution + relapse on dietary challenge
• D. No relapse after dietary changes

Answer: (C)

FRE is confirmed when symptoms disappear on a strict elimination diet and then reappear when the previous diet is reintroduced. This two-step pattern shows that the GI signs are driven by dietary antigens. Improvement alone could be due to other factors, and relapse on challenge alone doesn’t prove the diet was the trigger without an initial positive response to elimination. The combination of clinical resolution with an elimination diet plus relapse upon dietary re-challenge best demonstrates diet-driven enteropathy.

FRE is confirmed when symptoms disappear on a strict elimination diet and then reappear when the previous diet is reintroduced. This two-step pattern shows that the GI signs are driven by dietary antigens. Improvement alone could be due to other factors, and relapse on challenge alone doesn’t prove the diet was the trigger without an initial positive response to elimination. The combination of clinical resolution with an elimination diet plus relapse upon dietary re-challenge best demonstrates diet-driven enteropathy.