Which combination describes FRE confirmation criteria?

Which combination describes FRE confirmation criteria?

• A. Clinical resolution
• B. Relapse on dietary challenge
• C. Both Clinical resolution and relapse on dietary challenge
• D. Neither

Answer: (C)

The key idea is that diagnosing diet-responsive enteropathy relies on a clear, cause‑and‑effect pattern with diet. If a patient improves when kept on a strict elimination diet, that shows the diet can control the disease. But to confirm that diet is the trigger, you also need to see the disease flare again when the original or suspected dietary antigen is reintroduced (dietary challenge). Seeing both clinical resolution on the elimination diet and relapse on reintroduction demonstrates a causal link between the diet and the enteropathy, which is why this combination is the best answer.

The key idea is that diagnosing diet-responsive enteropathy relies on a clear, cause‑and‑effect pattern with diet. If a patient improves when kept on a strict elimination diet, that shows the diet can control the disease. But to confirm that diet is the trigger, you also need to see the disease flare again when the original or suspected dietary antigen is reintroduced (dietary challenge). Seeing both clinical resolution on the elimination diet and relapse on reintroduction demonstrates a causal link between the diet and the enteropathy, which is why this combination is the best answer.